Increasing evidence suggest functional roles of subepithelial mesenchymal niche cells in maintaining intestinal stem cells and in modulating the pathogenesis of various intestinal diseases in mammals. A recent study reported the discovery of a new population of stromal cells in mice termed MAP3K2-Regulated Intestinal Stromal Cells (MRISCs); these cells reside at the base of colonic crypt and function to protect colonic stem cells during colonic inflammation by expressing the Wnt agonist R-spondin1 (Rspo1).
Guoli Zhu, Rongwen Xi. MRISCs protect colonic stem cells from inflammatory damage. Cell regeneration (London, England). 2021 Jun 03;10(1):24
PMID: 34080092
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