Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability.

Maddalena Mognato, Susanne Burdak-Rothkamm, Kai Rothkamm

Mutation research. Reviews in mutation research 2021 Jan-Jun

filter terms:

DNA replication stress is a major source of DNA damage, including double-stranded breaks that promote DNA damage response (DDR) signaling. Inefficient repair of such lesions can affect genome integrity. During DNA replication different factors act on chromatin remodeling in a coordinated way. While recent studies have highlighted individual molecular mechanisms of interaction, less is known about the orchestration of chromatin changes under replication stress. In this review we attempt to explore the complex relationship between DNA replication stress, DDR and genome integrity in mammalian cells, taking into account the role of chromatin disposition as an important modulator of DNA repair. Recent data on chromatin restoration and epigenetic re-establishment after DNA replication stress are reviewed. Copyright © 2020 Elsevier B.V. All rights reserved.

Citation

Maddalena Mognato, Susanne Burdak-Rothkamm, Kai Rothkamm. Interplay between DNA replication stress, chromatin dynamics and DNA-damage response for the maintenance of genome stability. Mutation research. Reviews in mutation research. 2021 Jan-Jun;787:108346