Interleukins in cancer: from biology to therapy.

Daria Briukhovetska, Janina Dörr, Stefan Endres, Peter Libby, Charles A Dinarello, Sebastian Kobold

Nature reviews. Cancer 2021 Aug

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Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects. This Review aims to unravel some of these complex interactions. © 2021. Springer Nature Limited.

Citation

Daria Briukhovetska, Janina Dörr, Stefan Endres, Peter Libby, Charles A Dinarello, Sebastian Kobold. Interleukins in cancer: from biology to therapy. Nature reviews. Cancer. 2021 Aug;21(8):481-499