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Lower-grade gliomas(LGGs)belong to the group of World Health Organization(WHO)grade II and grade III brain tumors and are slow-growing primary brain tumors. Surgical resection is the initial first-line treatment, followed by chemotherapy, while radiotherapy is often reserved in case of recurrence. Based on the WHO 2016 molecular classification, LGGs are genetically classified into three distinct subtypes based on isocitrate dehydrogenase(IDH)mutation status and codeletion of chromosome 1p and 19q(1p/19q). Due to the differences in tumor characteristics of these molecular subtypes, a standard therapy optimized for these subtypes should be established. This review shows the present evidence and recommended standard therapy for LGGs and discusses several issues to be considered.


Kazuya Motomura. Lower-grade Gliomas]. No shinkei geka. Neurological surgery. 2021 May;49(3):632-639

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PMID: 34092569

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