Cs2CO3-Promoted Hydrothiolation of Alkynes with Aryl Thioureas: Stereoselective Synthesis of (Z)-Vinyl Sulfides.

A metal-free Cs2CO3-promoted hydrothiolation of alkynes with aryl thioureas for stereoselective synthesis of (Z)-vinyl sulfides has been reported. Vinyl thioethers were obtained without a metal catalyst in good yields via anti-Markovnikov and cis addition. The protocol features a broad substrate scope of the starting materials, high atom economy, good yields, and exclusive stereoselectivity, showing potential synthetic value for the synthesis of a diversity of (Z)-vinyl thioethers.

Citation

Dan Wang, Han-Ying Peng, Meng-Meng Yang, Er-Jun Hao, Yue-Sheng Li, Zhi-Bing Dong. Cs2CO3-Promoted Hydrothiolation of Alkynes with Aryl Thioureas: Stereoselective Synthesis of (Z)-Vinyl Sulfides. The Journal of organic chemistry. 2021 Jun 18;86(12):8457-8464

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PMID: 34100610

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