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COVID-19, a pandemic disease caused by a viral infection, is associated with a high mortality rate. Most of the signs and symptoms, e.g. cytokine storm, electrolytes imbalances, thromboembolism, etc., are related to mitochondrial dysfunction. Therefore, targeting mitochondrion will represent a more rational treatment of COVID-19. The current work outlines how COVID-19's signs and symptoms are related to the mitochondrion. Proper understanding of the underlying causes might enhance the opportunity to treat COVID-19.


Khalid Omer Alfarouk, Sari T S Alhoufie, Abdelhameed Hifny, Laurent Schwartz, Ali S Alqahtani, Samrein B M Ahmed, Ali M Alqahtani, Saad S Alqahtani, Abdel Khalig Muddathir, Heyam Ali, Adil H H Bashir, Muntaser E Ibrahim, Maria Raffaella Greco, Rosa A Cardone, Salvador Harguindey, Stephan Joel Reshkin. Of mitochondrion and COVID-19. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec;36(1):1258-1267

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PMID: 34107824

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