Nickel-Catalyzed Thiolation of Aryl Nitriles.

Tristan Delcaillau, Bill Morandi

Chemistry (Weinheim an der Bergstrasse, Germany) 2021 Aug 16

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A nickel-catalyzed thiolation of aryl nitriles has been developed to access functionalized aryl thioethers. The ligand dcype (1,2-bis(dicyclohexylphosphino)ethane) as well as the base KOt Bu (potassium tert-butoxide) are essential to achieve this transformation. This scalable and practical process involves both a C-C bond activation and a C-S bond formation. Furthermore, this reaction shows a high functional-group tolerance and enables the late-stage functionalization of important molecules. © 2021 The Authors. Published by Wiley-VCH GmbH.

Citation

Tristan Delcaillau, Bill Morandi. Nickel-Catalyzed Thiolation of Aryl Nitriles. Chemistry (Weinheim an der Bergstrasse, Germany). 2021 Aug 16;27(46):11823-11826