Epigenetic Regulation of Hepatocellular Carcinoma Progression through the mTOR Signaling Pathway.

Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is an aggressive tumor with a high mortality rate because of the limited systemic and locoregional treatment modalities. The development and progression of HCC depend on epigenetic changes that result in the activation or inhibition of some signaling pathways. The mTOR signaling pathway is essential for many pathophysiological processes and is considered a major regulator of cancer. Increasing evidence has shown that epigenetics plays a key role in HCC biology by regulating the mTOR signaling pathway. Therefore, epigenetic regulation through the mTOR signaling pathway to diagnose and treat HCC will become a very promising strategy. Copyright © 2021 Mengnan Guo et al.

Citation

Mengnan Guo, Ning Li, Jianxia Zheng, Wei Wang, Yan Wu, Xu Han, Jiapei Guo, Weixi Chen, Zekun Bai, Wen Bai, Jinghua Wu. Epigenetic Regulation of Hepatocellular Carcinoma Progression through the mTOR Signaling Pathway. Canadian journal of gastroenterology & hepatology. 2021;2021:5596712

Mesh Tags

Substances

PMID: 34123955

search → result