Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase.

Jian Qiao, Mingying Wang, Menghan Cui, Yuxi Fang, Haonan Li, Chao Zheng, Zhanlin Li, Yongnan Xu, Huiming Hua, Dahong Li

Journal of pharmaceutical and biomedical analysis 2021 Sep 05

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Nitroreductase is a reductase that catalyzes nitro aromatic compounds to aromatic amines. It effectively reduces nitro to hydroxylamine or amino when in the presence of nicotinamide adenine dinucleotide or nicotinamide adenine dinucleotide phosphate. In terms of tumor, nitroreductase is upregulated in hypoxic tumor cells, and its content is directly related to the degree of hypoxia. Therefore, effective detection of nitroreductase is important not only for the study of cellular hypoxia, but also for the diagnosis and treatment of tumors and related diseases. In this review, we summarized the latest advances in small-molecule fluorescent probes for nitroreductase detection based on different fluorescence mechanisms, with a focus on research conducted between May 2018 and December 2020. The development trends and application prospect in this rapidly developing field were also highlighted. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Jian Qiao, Mingying Wang, Menghan Cui, Yuxi Fang, Haonan Li, Chao Zheng, Zhanlin Li, Yongnan Xu, Huiming Hua, Dahong Li. Small-molecule probes for fluorescent detection of cellular hypoxia-related nitroreductase. Journal of pharmaceutical and biomedical analysis. 2021 Sep 05;203:114199