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l-lysine is an essential amino acid that contains various functional groups including α-amino, ω-amino, and α-carboxyl groups, exhibiting high reaction potential. The derivatization of these functional groups produces a series of value-added chemicals, such as cadaverine, glutarate, and d-lysine, that are widely applied in the chemical synthesis, cosmetics, food, and pharmaceutical industries. Here, we review recent advances in the biotechnological production of l-lysine and its derivatives and expatiate key technological strategies. Furthermore, we also discuss the existing challenges and potential strategies for more efficient production of these chemicals. Copyright © 2021 Elsevier Inc. All rights reserved.


Jiaping Wang, Cong Gao, Xiulai Chen, Liming Liu. Expanding the lysine industry: biotechnological production of l-lysine and its derivatives. Advances in applied microbiology. 2021;115:1-33

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PMID: 34140131

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