Emergence and genomics of OXA-232-producing Klebsiella pneumoniae in a hospital in Yancheng, China.

The aims of this study were to infer the phylogenetic relationship of OXA-232-producing Klebsiella pneumoniae (OXA232Kp) strains collected from a Chinese hospital and to determine the composition and genetic background of antimicrobial resistance genes (ARGs) among these strains. Three non-duplicate OXA232Kp strains were collected from a Chinese hospital. Whole-genome sequencing was used to determine their genome sequences and then a genomic comparison of ARG-carrying genetic elements from the three strains with related sequences was performed. Phylogenetic analysis was conducted by constructing a maximum-likelihood phylogenetic tree. Compared with other Chinese sequence type 15 (ST15)-OXA232Kp strains, the three ST15-OXA232Kp strains in this study could be divided into a single subgroup in phylogenetic relationship. The composition and genetic background of ARGs were identical in the three strains. Three ARG-carrying genetic elements or multidrug resistance (MDR) regions were determined, including a truncated Tn2013-like IS-based transposition unit, a unit transposition Tn6867b and a 40.9-kb MDR region. This study reported clonal dissemination of ST15-OXA232Kp strains carrying multiple ARGs in a Chinese hospital. A comprehensive evolutionary and genomics analysis provided a deeper understanding of OXA232Kp. Further surveillance and study should be advocated to prevent the dissemination of OXA232Kp strains in China. Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

Citation

Zhichen Zhu, Haifeng Huang, Yumei Xu, Min Wang, Jinnan Lv, Linlin Xu, Chunlei Shi, Ya Xu, Ruifu Yang, Liang Chen, Hong Du. Emergence and genomics of OXA-232-producing Klebsiella pneumoniae in a hospital in Yancheng, China. Journal of global antimicrobial resistance. 2021 Sep;26:194-198

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PMID: 34146740

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