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Hydrosilane-Mediated Electrochemical Reduction of Amides.
Kazuhiro Okamoto, Shingo Nagahara, Yasushi Imada, Risako Narita, Yoshikazu Kitano, Kazuhiro Chiba
The Journal of organic chemistry 2021 Nov 19Sizes of these terms reflect their relevance to your search.
Electrochemical reduction of amides was achieved by using a hydrosilane without any toxic or expensive metals. The key reactive ketyl radical intermediate was generated by cathodic reduction. Continuous reaction with anodically generated silyl radicals or zinc bromide resulted in chemoselective deoxygenation to give the corresponding amines.
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Kazuhiro Okamoto, Shingo Nagahara, Yasushi Imada, Risako Narita, Yoshikazu Kitano, Kazuhiro Chiba. Hydrosilane-Mediated Electrochemical Reduction of Amides. The Journal of organic chemistry. 2021 Nov 19;86(22):15992-16000
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PMID: 34152146
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