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Salvia officinalis (Lamiaceae) and Lippia triphylla (Verbenaceae) are two plants known for their therapeutic effects in conventional medicine for the treatment of a wide extent of diseases, including the ones on the central nervous system. In the present study, the impact of aqueous extract from the leaves of these two herbs for the treatment of depression was examined. The phytochemical profile highlighted the presence of eighteen and ten polyphenolic compounds in Salvia officinalis and Lippia triphylla, respectively. The antidepressant effects of such extracts were assessed using two tests: the forced swimming test (FST) and tail suspension test (TST) in swiss albino mice. Five mice were partitioned into each group: control (distilled water), standard (Imipramine hydrochloride, 25 mg/kg) and three test ones treated with increased doses of aqueous extracts (250-500-1000 mg/kg), orally administered for two weeks. The acute treatment of the mice with aqueous extracts of Salvia officinalis and Lippia triphylla reduced significantly the time of immobility in the forced swimming test (p < 0.001) as compared to control group, and also decreased significantly the time of immobility of mice in the tail suspension test (p < 0.001). The findings attained in this work show how both plants possess potential anti-depressant-like effects; however, the translation from the results presented in this work to a potential use as therapeutic agents would require the acquisition of a stronger scientific evidence. Copyright © 2021 Elsevier B.V. All rights reserved.


Imane Maliki, Imane Es-Safi, Abdelfattah El Moussaoui, Hamza Mechchate, Yassine Oulad El Majdoub, Aziz Bouymajane, Francesco Cacciola, Luigi Mondello, Khalid Elbadaoui. Salvia officinalis and Lippia triphylla: Chemical characterization and evaluation of antidepressant-like activity. Journal of pharmaceutical and biomedical analysis. 2021 Sep 05;203:114207

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PMID: 34153940

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