APOL1-associated kidney disease in northern Nigerians with treated HIV infection.

Opeyemi A Olabisi, Barry I Freedman

Kidney international 2021 Jul

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Apolipoprotein L1 (APOL1) high-risk genotypes strongly associate with HIV-associated nephropathy, and antiretroviral therapy reduces the incidence of HIV-associated nephropathy and progression to end-stage kidney disease. Wudil et al. report cross-sectional APOL1 associations with proteinuria and estimated glomerular filtration rate in a northern Nigerian sample with HIV infection on antiretroviral therapy. Multiple ethnic groups with different APOL1 risk variant frequencies were included. Overall, APOL1 was associated with proteinuric chronic kidney disease; however, relationships with underlying causes of nephropathy and progression rates require further study. Copyright © 2021 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Citation

Opeyemi A Olabisi, Barry I Freedman. APOL1-associated kidney disease in northern Nigerians with treated HIV infection. Kidney international. 2021 Jul;100(1):19-21