Nuclear factor-kappa B and its role in inflammatory lung disease.

Chemico-biological interactions 2021 Aug 25

filter terms:

Nuclear factor-kappa B, involved in inflammation, host immune response, cell adhesion, growth signals, cell proliferation, cell differentiation, and apoptosis defense, is a dimeric transcription factor. Inflammation is a key component of many common respiratory disorders, including asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, and acute respiratory distress syndrome. Many basic transcription factors are found in NF-κB signaling, which is a member of the Rel protein family. Five members of this family c-REL, NF-κB2 (p100/p52), RelA (p65), NF-κB1 (p105/p50), RelB, and RelA (p65) produce 5 transcriptionally active molecules. Proinflammatory cytokines, T lymphocyte, and B lymphocyte cell mitogens, lipopolysaccharides, bacteria, viral proteins, viruses, double-stranded RNA, oxidative stress, physical exertion, various chemotherapeutics are the stimulus responsible for NF-κB activation. NF-κB act as a principal component for several common respiratory illnesses, such as asthma, lung cancer, pulmonary fibrosis, COPD as well as infectious diseases like pneumonia, tuberculosis, COVID-19. Inflammatory lung disease, especially COVID-19, can make NF-κB a key target for drug production. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Khalid Saad Alharbi, Neeraj Kumar Fuloria, Shivkanya Fuloria, Sk Batin Rahman, Waleed Hassan Al-Malki, Mohammad Arshad Javed Shaikh, Lakshmi Thangavelu, Sachin K Singh, Venkata Sita Rama Raju Allam, Niraj Kumar Jha, Dinesh Kumar Chellappan, Kamal Dua, Gaurav Gupta. Nuclear factor-kappa B and its role in inflammatory lung disease. Chemico-biological interactions. 2021 Aug 25;345:109568