Correlation Engine 2.0
Clear Search sequence regions


  • carp (3)
  • cellular (1)
  • factors (2)
  • impairment (1)
  • Interferon (4)
  • irf3 (8)
  • irf7 (7)
  • irf7 protein, zebrafish (1)
  • OTU (2)
  • otud6b (8)
  • regulates (1)
  • repress (1)
  • tbk1 (1)
  • traf6 (1)
  • viremia (2)
  • zebrafish (5)
  • zebrafish proteins (2)
  • Sizes of these terms reflect their relevance to your search.

    Ovarian tumor domain-containing 6B (OTUD6B) belongs to the OTU deubiquitylating enzyme family. In this study, we report that zebrafish otud6b is induced upon viral infection, and overexpression of otud6b suppresses cellular antiviral response. Disruption of otud6b in zebrafish increases the survival rate upon spring viremia of carp virus and grass carp reovirus exposure. Further assays indicate that otud6b interacts with irf3 and irf7 and diminishes traf6-mediated K63-linked polyubiquitination of irf3 and irf7. In addition, the OTU domain is required for otud6b to repress IFN-1 activation and K63-linked polyubiquitination of irf3 and irf7. Moreover, otud6b also attenuates tbk1 to bind to irf3 and irf7, resulting in the impairment of irf3 and irf7 phosphorylation. This study provides, to our knowledge, novel insights into otud6b function and sheds new lights on the regulation of irf3 and irf7 by deubiquitination in IFN-1 signaling. Copyright © 2021 by The American Association of Immunologists, Inc.

    Citation

    Ziwen Zhou, Xiaolian Cai, Junji Zhu, Zhi Li, Guangqing Yu, Xing Liu, Gang Ouyang, Wuhan Xiao. Zebrafish otud6b Negatively Regulates Antiviral Responses by Suppressing K63-Linked Ubiquitination of irf3 and irf7. Journal of immunology (Baltimore, Md. : 1950). 2021 Jul 01;207(1):244-256

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 34183367

    View Full Text