The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster.

L S Melnikova, V V Molodina, M V Kostyuchenko, P G Georgiev, A K Golovnin

Doklady. Biochemistry and biophysics 2021 May

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In Drosophila, the BEAF-32, Z4/putzig, and Chriz/Chromator proteins colocalize in the interbands of polytene chromosomes. It was assumed that these proteins can form a complex that affects the structure of chromatin. However, the mechanism of the formation of such a complex has not been studied. We have proved for the first time that the BEAF-32, Z4/putzig, and Chriz/Chromator proteins interact directly with each other and localized the protein domains that provide multiple protein-protein interactions. Based on the data obtained, we developed a model of the mechanism of the formation the BEAF/Z4/Chriz complex and its recruitment to chromatin.

Citation

L S Melnikova, V V Molodina, M V Kostyuchenko, P G Georgiev, A K Golovnin. The BEAF-32 Protein Directly Interacts with Z4/putzig and Chriz/Chromator Proteins in Drosophila melanogaster. Doklady. Biochemistry and biophysics. 2021 May;498(1):184-189