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This study aimed to optimize the size of capsule-shaped 3D-printed devices (CPD) using an experimental design by the response surface methodology to provide a gastroretentive drug delivery system (GRDDS) with optimal floating time. The CPD was fabricated using a fused deposition modeling (FDM) 3D printer. The central composite design was employed for the optimization of the devices. The morphology of the CPD was observed using a digital microscope and scanning electron microscope (SEM). The in vitro floating time and drug release were evaluated using a USP dissolution apparatus II. Appropriate total floating time (TFT) of the devices (more than 3 h) was obtained with the device's body, cap, and bottom thickness of 1.2, 1.8, and 2.9 mm, respectively. The release kinetics of the drug from the devices fitted well with zero-order kinetics. In conclusion, the optimization of CPD for GRDDS using the experimental design provided the devices with desirable floating time and ideal drug release characteristics.


Thapakorn Charoenying, Prasopchai Patrojanasophon, Tanasait Ngawhirunpat, Theerasak Rojanarata, Prasert Akkaramongkolporn, Praneet Opanasopit. Design and Optimization of 3D-Printed Gastroretentive Floating Devices by Central Composite Design. AAPS PharmSciTech. 2021 Jun 30;22(5):197

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PMID: 34191172

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