Cohesin Mutations in Cancer: Emerging Therapeutic Targets.

Jisha Antony, Chue Vin Chin, Julia A Horsfield

International journal of molecular sciences 2021 Jun 24

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The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal three-dimensional organization of the genome. Mutations in cohesin genes are present in a range of cancers. Extensive research over the last few years has shown that cohesin mutations are key events that contribute to neoplastic transformation. Cohesin is involved in a range of cellular processes; therefore, the impact of cohesin mutations in cancer is complex and can be cell context dependent. Candidate targets with therapeutic potential in cohesin mutant cells are emerging from functional studies. Here, we review emerging targets and pharmacological agents that have therapeutic potential in cohesin mutant cells.

Citation

Jisha Antony, Chue Vin Chin, Julia A Horsfield. Cohesin Mutations in Cancer: Emerging Therapeutic Targets. International journal of molecular sciences. 2021 Jun 24;22(13)