Cp*CoIII-Catalyzed C(7)-H Bond Annulation of Indolines with Alkynes.

Rajib Mandal, Bholanath Garai, Basker Sundararaju

The Journal of organic chemistry 2021 Jul 16

filter terms:

An efficient protocol for the synthesis of biologically essential pyrroloquinolinones has been developed under Cp*CoIII catalysis, which involves a cascade reaction of C(7)-H alkenylation with alkynes followed by nucleophilic addition. A wide variety of internal alkynes including enyne, diyne, and ynamide and more challenging terminal alkynes were successfully employed for the annulation in good to excellent yield with high regioselectivity.

Citation

Rajib Mandal, Bholanath Garai, Basker Sundararaju. Cp*CoIII-Catalyzed C(7)-H Bond Annulation of Indolines with Alkynes. The Journal of organic chemistry. 2021 Jul 16;86(14):9407-9417