Roles of exosomes-derived lncRNAs in preeclampsia.

Rong-Quan Gong, Abdifatah Mohamed Nuh, Heng-Shan Cao, Min Ma

European journal of obstetrics, gynecology, and reproductive biology 2021 Aug

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Preeclampsia is a pregnancy-specific hypertensive syndrome, which seriously threatens the safety of mother and infant. However, there is still no accurate biomarkers for the diagnosis of preeclampsia, and its etiology and pathogenesis have not been fully elucidated. Exosomes are extracellular vesicles widely existing in body fluids, which carry a variety of bioactive molecules such as proteins, lipids and nucleic acids with various biological functions. The lncRNAs carried by exosomes are characterized by specificity, plurality, anti-degradation and stable detection. Multiple differentially expressed lncRNAs were found in exosomes secreted by placental tissues of patients with preeclampsia, suggesting that they may be involved in the occurrence and development of preeclampsia. In this paper, we summarized the structures and functions of exosomes-derived lncRNAs and their relationships with preeclampsia in order to provide new ideas for the pathogenesis, early prediction, diagnosis and treatment of preeclampsia. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Rong-Quan Gong, Abdifatah Mohamed Nuh, Heng-Shan Cao, Min Ma. Roles of exosomes-derived lncRNAs in preeclampsia. European journal of obstetrics, gynecology, and reproductive biology. 2021 Aug;263:132-138