Quantification of smooth pursuit dysfunction in multiple sclerosis.

Smooth pursuit dysfunction is common in MS, but rarely quantified and may be missed on exam. NeuroFitONE™ smooth pursuit performance measures were compared between MS (n = 20) and healthy control (n = 19) participants. Compared to controls, MS patients had lower proportion of smooth pursuit (0.63 vs. 0.73; p = 0.047), increased directional (10.1 vs. 8°; p = 0.014) and speed noise (4.3 vs. 3.1°/sec; p = 0.021) and reduced initiation acceleration (96.83 vs. 115.33°/sec2; p = 0.061). Significant univariate correlations with clinical scores (EDSS, T25-FW) were observed. Smooth pursuit dysfunction in MS can be readily quantified and distinguishes MS eyes from healthy controls. Copyright © 2021. Published by Elsevier B.V.

Citation

Torge Rempe, Neda Dastgheyb, Annalise Miner, Miryam Palomino, Revere Kinkel, Dorion Liston, Jennifer S Graves. Quantification of smooth pursuit dysfunction in multiple sclerosis. Multiple sclerosis and related disorders. 2021 Sep;54:103073

Mesh Tags

PMID: 34214878

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