Letrozole, an aromatase inhibitor that blocks estrogen synthesis by inhibiting the final step of the estrogen biosynthetic pathway, has been used in the applications of a wide range of infertility settings. It has been more than 20 years since the initial clinical trial of letrozole for ovulation induction. In light of the accumulating clinical and basic evidence, the efficacy and safety of letrozole have been identified. This mini review focuses on our current knowledge of the applications and mechanisms of letrozole for female infertility and various questions are put forward about how letrozole could be more effectively used. Copyright © 2021 Yang, Cui, Sun and Hao.
Ai-Min Yang, Na Cui, Yi-Fei Sun, Gui-Min Hao. Letrozole for Female Infertility. Frontiers in endocrinology. 2021;12:676133
PMID: 34220713
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