Sestrin2 in hypoxia and hypoxia-related diseases.

Xiaojing Che, Jiagui Chai, Yan Fang, Xifeng Zhang, Anju Zu, Lin Li, Shibo Sun, Weimin Yang

Redox report : communications in free radical research 2021 Dec

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Objectives: Sestrin2 is a stress-inducible protein and play an important role in adapting stress states of cells. This article reviewed the role of Sestrin2 in hypoxia and hypoxia-related diseases to provide new perspectives for future research and new therapeutic targets for hypoxia-related diseases.Methods: A review was conducted through an electronic search of PubMed and Medline databases. Keywords included Sestrin2, ROS, hypoxia, and hypoxia-related disease. Articles from 2008 to 2021 were mostly included and older ones were not excluded.Results: Sestrin2 is upregulated under various stress conditions, especially hypoxia. Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway. In addition, Sestrin2 is involved in various hypoxia-related diseases, such as cerebral hypoxic disease, myocardial hypoxic disease, hypoxia-related respiratory disease, and diabetes.Discussion: Sestrin2 is involved in various hypoxia-related diseases and maybe a therapeutic target. Furthermore, most studies focus on cerebral and myocardial ischemia reperfusion. More researches on hypoxia-related respiratory diseases, kidney injury, and diabetes are needed in future.

Citation

Xiaojing Che, Jiagui Chai, Yan Fang, Xifeng Zhang, Anju Zu, Lin Li, Shibo Sun, Weimin Yang. Sestrin2 in hypoxia and hypoxia-related diseases. Redox report : communications in free radical research. 2021 Dec;26(1):111-116