Desmoid fibromatosis: is the current picture changing?

Saneya Pandrowala, Robin L Jones, Sanjay Gupta, Ashish Gulia

Future oncology (London, England) 2021 Sep

filter terms:

Desmoid fibromatosis is a locally aggressive tumor with an unpredictable clinical course. Surgery was once the mainstay of treatment, but the treatment protocol has been constantly evolving and currently active surveillance is the front-line approach. There have been significant insights into the molecular biology with the addition of mutational analysis of CTNNB1 adding to prognostic information. We present a review of the literature with current practice guidelines, also including novel therapeutic targets and ongoing clinical trials, to unravel the next step in the management of sporadic desmoid fibromatosis.

Citation

Saneya Pandrowala, Robin L Jones, Sanjay Gupta, Ashish Gulia. Desmoid fibromatosis: is the current picture changing? Future oncology (London, England). 2021 Sep;17(25):3397-3408