Biosensing with DNAzymes.

Erin M McConnell, Ioana Cozma, Quanbing Mou, John D Brennan, Yi Lu, Yingfu Li

Chemical Society reviews 2021 Aug 21

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This article provides a comprehensive review of biosensing with DNAzymes, providing an overview of different sensing applications while highlighting major progress and seminal contributions to the field of portable biosensor devices and point-of-care diagnostics. Specifically, the field of functional nucleic acids is introduced, with a specific focus on DNAzymes. The incorporation of DNAzymes into bioassays is then described, followed by a detailed overview of recent advances in the development of in vivo sensing platforms and portable sensors incorporating DNAzymes for molecular recognition. Finally, a critical perspective on the field, and a summary of where DNAzyme-based devices may make the biggest impact are provided.

Citation

Erin M McConnell, Ioana Cozma, Quanbing Mou, John D Brennan, Yi Lu, Yingfu Li. Biosensing with DNAzymes. Chemical Society reviews. 2021 Aug 21;50(16):8954-8994