Selenium concentrations in elderly people with Alzheimer's disease: a cross-sectional study with control group.

To investigate possible differences in plasma and erythrocyte concentrations of selenium among elderly with and without a diagnosis of Alzheimer's disease (AD). Cross-sectional study, performed with an elderly group with Alzheimer's disease, diagnosed by a geriatric doctor, and compared to an elderly group without the disease, equaling gender, education, and age. Atomic absorption spectrophotometry determined plasma and erythrocyte concentrations of total selenium (Set). The mean age was 74.41±7.1 years in the Alzheimer's disease group and 71.46±5.1 years among the control group. The Alzheimer's disease group presented lower plasma concentrations (mean of 45.29±14.51 µg/dL vs. 55.14±14.01 µg/dL; p=0.004), and erythrocyte Set (median of 56.36 µg/L vs. 76.96 µg/L; p<0.001). The logistic regression model indicated an association between erythrocyte Set concentrations and diagnosis of Alzheimer's disease (p=0.028). Elderly with Alzheimer's disease present lower selenium concentrations in the evaluated organic compartments.

Citation

Carlos Queiroz do Nascimento, João Araújo Barros-Neto, Nathalia Fidelis Lins Vieira, José Antonio Menezes-Filho, Sabrina Joanny Felizardo Neves, Sonia Oliveira Lima. Selenium concentrations in elderly people with Alzheimer's disease: a cross-sectional study with control group. Revista brasileira de enfermagem. 2021;74Suppl 2(Suppl 2):e20200984

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PMID: 34231781

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