Phosphodiesterase 7(PDE7): A unique drug target for central nervous system diseases.

Ying Chen, Hao Wang, Wen-Zhi Wang, Dong Wang, Keith Skaggs, Han-Ting Zhang

Neuropharmacology 2021 Sep 15

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Phosphodiesterase 7 (PDE7), one of the 11 phosphodiesterase (PDE) families, specifically hydrolyzes cyclic 3', 5'-adenosine monophosphate (cAMP). PDE7 is involved in many important functional processes in physiology and pathology by regulating intracellular cAMP signaling. Studies have demonstrated that PDE7 is widely expressed in the central nervous system (CNS) and potentially related to pathogenesis of many CNS diseases. Here, we summarized the classification and distribution of PDE7 in the brain and its functional roles in the mediation of CNS diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), and schizophrenia. It is expected that the findings collected here will not only lead to a better understanding of the mechanisms by which PDE7 mediates CNS function and diseases, but also aid in the development of novel drugs targeting PDE7 for treatment of CNS diseases. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Ying Chen, Hao Wang, Wen-Zhi Wang, Dong Wang, Keith Skaggs, Han-Ting Zhang. Phosphodiesterase 7(PDE7): A unique drug target for central nervous system diseases. Neuropharmacology. 2021 Sep 15;196:108694