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To examine oral colonization and virulence factors of Candida spp. in patients aged from 0 to 18 months with cleft palate (CP). Sixty babies were allocated into 3 groups: CP, CP with orthodontic plate (CPwP), and control group (Ctrl) without CP. Information on feeding habits, hygiene, and history of candidosis was collected. The presence of Candida spp. was investigated in samples of saliva. Fungal hydrophobicity, protease, esterase, phospholipase, and hemolysin were evaluated in a semiquantitative manner. Positive oral isolations of Candida spp. were detected in CP (89.5%), CPwP (100%), and Ctrl (44%) groups. Candidosis was more reported in the cleft groups than in the Ctrl group (P ≤ .023). There was a higher prevalence of Candida albicans, followed by Candida krusei, Candida tropicalis, and Candida parapsilosis in all groups. There was no uniformity of expression of virulence factors, either among different species or among different groups. Candida spp. colonization occurred in all groups, being superior in CPwP group. Candidosis episodes were more reported in patients from CPwP than in other groups, although candidosis was also registered in other groups. Candida albicans was the predominant species and virulence factors did not exhibit any pattern for species or groups of patients.


Patrícia Tolentino da Rosa de Souza, Nilza Cristina Valor Gonçalves-Wilhelmsen, Rosimeire Takaki Rosa, Clarice de Fatima Kamaroski Noan Correia, Thais Munhoz Pereira, Aldini Beuting Pereira Kitahara, Sérgio Aparecido Ignácio, Luciana Reis Azevedo-Alanis, Edvaldo Antônio Ribeiro Rosa. Oral Colonization and Virulence Factors of Candida spp. in Babies With Cleft Palate. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association. 2021 Jul 14:10556656211030437

PMID: 34259068

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