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Peripherin (PRPH), a type III intermediate filament, assembles with neurofilaments in neurons of the peripheral nervous system, including lower motor neurons (LMN). To evaluate the role of PRPH in LMN degeneration, we assessed PRPH and neurofilament light chain (NfL) in cerebrospinal fluid (CSF) and serum of 91 patients with motor neuron diseases (MND) and 69 controls. Overall, we found PRPH to be more concentrated in serum than in CSF. Serum PRPH resulted significantly increased in MND patients but it was unrelated to CSF-NfL or survival in the amyotrophic lateral sclerosis (ALS) subset. PRPH might represent a marker of LMN involvement. © 2021 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association.

Citation

Daniele Sabbatini, Flavia Raggi, Susanna Ruggero, Mara Seguso, Jessica Mandrioli, Annachiara Cagnin, Chiara Briani, Elisabetta Toffanin, Matteo Gizzi, Andrea Fortuna, Luca Bello, Elena Pegoraro, Giulia Musso, Gianni Sorarù. Evaluation of peripherin in biofluids of patients with motor neuron diseases. Annals of clinical and translational neurology. 2021 Aug;8(8):1750-1754

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PMID: 34264016

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