Polycomb-group proteins in the initiation and progression of cancer.

Xiujuan Zhao, Xudong Wu

Journal of genetics and genomics = Yi chuan xue bao 2021 Jun 20

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The Polycomb group (PcG) proteins are a family of chromatin regulators and critical for the maintenance of cellular identity. The PcG machinery can be categorized into at least three multi-protein complexes, namely Polycomb Repressive Complex 1 (PRC1), PRC2, and Polycomb Repressive DeUBiquitinase (PR-DUB). Their deregulation has been associated with human cancer initiation and progression. Here we review the updated understanding for PcG proteins in transcription regulation and DNA damage repair and highlight increasing links to the hallmarks in cancer. Accordingly, we discuss some of the recent advances in drug development or strategies against cancers caused by the gain or loss of PcG functions. Copyright © 2021 Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Ltd. All rights reserved.

Citation

Xiujuan Zhao, Xudong Wu. Polycomb-group proteins in the initiation and progression of cancer. Journal of genetics and genomics = Yi chuan xue bao. 2021 Jun 20;48(6):433-443