Potassium Persulfate Mediated Chemodivergent C-3 Functionalization of 2H-Indazoles with DMSO as C1 Source.

Suvam Bhattacharjee, Sudip Laru, Payel Ghosh, Alakananda Hajra

The Journal of organic chemistry 2021 Aug 06

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A facile, efficient, and transition-metal-free chemodivergent C-3 functionalization of 2H-indazoles was developed under aerobic conditions using carboxylic acid and DMSO as the combined source of the carboxylic acid ester group and DMSO as the formylating agent. A series of formylated indazoles and carboxylic acid esters of indazole derivatives were produced in moderate to excellent yields. The mechanistic studies suggest that the reactions probably proceed through a radical pathway.

Citation

Suvam Bhattacharjee, Sudip Laru, Payel Ghosh, Alakananda Hajra. Potassium Persulfate Mediated Chemodivergent C-3 Functionalization of 2H-Indazoles with DMSO as C1 Source. The Journal of organic chemistry. 2021 Aug 06;86(15):10866-10873