Synthesis of analogues of amaninamide, an amatoxin from the white Amanita virosa mushroom.

G Zanotti, C Möhringer, T Wieland

C.N.R. Institute of Pharmaceutical Chemistry, University La Sapienza, Rome, Italy.

International journal of peptide and protein research 1987 Oct

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Analogs of amaninamide, due to the absence of a 6-hydroxy group in the tryptophan moiety, are more easily accessible by synthesis than derivatives of alpha-amanitin. Syntheses of bicyclic octapeptide thioethers 1f-1m have been carried out starting from linear Hpi-S-trityl-octapeptides (3), cyclization by intramolecular 2'-indolylthioether formation yielding monocyclic peptides (2) and final cyclization by DCCI. One of the bicyclic thioethers was oxidized to yield the corresponding chromatographically separated (R)- and (S)-sulfoxides, respectively. The products were characterized by RF-values, u.v. and CD spectra as well as by mass (FAB) spectroscopy. The widely differing inhibitory activities on RNA polymerase II (or B) from calf thymus are listed.

Citation

G Zanotti, C Möhringer, T Wieland. Synthesis of analogues of amaninamide, an amatoxin from the white Amanita virosa mushroom. International journal of peptide and protein research. 1987 Oct;30(4):450-9