Palladium-Catalyzed Direct C2-Biarylation of Indoles.

Biaryl and indole units are important structural motifs in several bioactive molecules and functional materials. We have accomplished straightforward access to C2-biarylated indole derivatives through palladium-catalyzed C-H activation strategy with a broad range of substrate scope in yields of 24 to 92%. Besides, the UV/visible absorption and fluorescence properties of the ensuing products were explored. The calculated higher dihedral angle and rotational barrier values for the selected C2-biarylated indoles show that these compounds may display atropisomerism at room temperature.

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Tamilarasu Murugesan, Chinraj Sivarajan, Chithra Mohan Jayakumari, Rajat Kumar Singh, Sivaranjana Reddy Vennapusa, Alagiri Kaliyamoorthy. Palladium-Catalyzed Direct C2-Biarylation of Indoles. The Journal of organic chemistry. 2021 Aug 06;86(15):10838-10851

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PMID: 34291945

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