Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats.

Seong Shoon Yoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, Chae Ha Yang

International journal of molecular sciences 2021 Jul 14

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Acupuncture affects the central nervous system via the regulation of neurotransmitter transmission. We previously showed that Shemen (HT7) acupoint stimulation decreased cocaine-induced dopamine release in the nucleus accumbens. Here, we used the intracranial self-stimulation (ICSS) paradigm to evaluate whether HT stimulation regulates the brain reward function of rats. We found that HT stimulation triggered a rightward shift of the frequency-rate curve and elevated the ICSS thresholds. However, HT7 stimulation did not affect the threshold-lowering effects produced by cocaine. These results indicate that HT7 points only effectively regulates the ICSS thresholds of the medial forebrain bundle in drug-naïve rats.

Citation

Seong Shoon Yoon, Jaesuk Yun, Bong Hyo Lee, Hee Young Kim, Chae Ha Yang. Acupuncture Modulates Intracranial Self-Stimulation of the Medial Forebrain Bundle in Rats. International journal of molecular sciences. 2021 Jul 14;22(14)