Correlation Engine 2.0
Clear Search sequence regions

  • CCL2 (1)
  • CCL3 (1)
  • CCL4 (1)
  • CXCL8 (1)
  • cytokines (3)
  • ERK 1 (6)
  • factor (2)
  • human (3)
  • immunoglobulin e (2)
  • MAPK3 protein (1)
  • mast cell (6)
  • mast cell- diseases (1)
  • mitogen (2)
  • mucosa (1)
  • patients (1)
  • polyphenol (1)
  • protein human (2)
  • receptors (2)
  • resveratrol (9)
  • signal (1)
  • STAT3 (7)
  • stat3 protein (1)
  • tnf α (1)
  • Sizes of these terms reflect their relevance to your search.

    Mast cells play a critical role as main effector cells in allergic and other inflammatory diseases. Usage of anti-inflammatory nutraceuticals could be of interest for affected patients. Resveratrol, a natural polyphenol found in red grapes, is known for its positive properties. Here, we analyzed the effects of resveratrol on FcεRI-mediated activation of mature human mast cells isolated from intestinal tissue (hiMC). Resveratrol inhibited degranulation and expression of cytokines and chemokines such as CXCL8, CCL2, CCL3, CCL4, and TNF-α in a dose-dependent manner. Further, resveratrol inhibited the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 and signal transducer and activator of transcription (STAT) 3. ERK1/2 is known to be involved in cytokine expression of hiMC and to directly interact with STAT3. Mitochondrial STAT3 is phosphorylated by ERK1/2 and contributes to mast cell degranulation. We were able to isolate mitochondrial fractions from small hiMC numbers and could show that activation of mitochondrial STAT3 and ERK1/2 in hiMC was also inhibited by resveratrol. Our results indicate that resveratrol inhibits hiMC activation by inhibiting the phosphorylation of mitochondrial and nuclear ERK1/2 and STAT3, and it could be considered as an anti-inflammatory nutraceutical in the treatment of mast cell-associated diseases.


    Sabrina Bilotta, Lakshmi Bhargavi Paruchuru, Katharina Feilhauer, Jörg Köninger, Axel Lorentz. Resveratrol Is a Natural Inhibitor of Human Intestinal Mast Cell Activation and Phosphorylation of Mitochondrial ERK1/2 and STAT3. International journal of molecular sciences. 2021 Jul 16;22(14)

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 34299258

    View Full Text