Dopaminergic denervation of the globus pallidus produces short-memory impairment in rats.

Rats with low-level globus pallidus (GP) dopaminergic denervation can develop anxiety without any motor alterations. The aim of this study was to evaluate the effect of low-level 6-OHDA-induced unilateral and bilateral GP lesions in male Wistar rats (n = 8/group) on recognition memory, motor activity, and the number of TH+ neurons in the SNc. For unilateral- and bilateral-lesioned animals, there was a significant decrease in the number of TH+ neurons (27% and 42%, respectively) and in the object, location, and temporal order discrimination indexes of recognition memory tests. Motor activity was unaffected. Thus, GP dopamine denervation was detrimental to short-memory. Copyright © 2021. Published by Elsevier Inc.

Citation

Katia Barón-Quiroz, Martha García-Ramirez, Eliezer Chuc-Meza. Dopaminergic denervation of the globus pallidus produces short-memory impairment in rats. Physiology & behavior. 2021 Oct 15;240:113535

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PMID: 34303714

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