Fluorination of 2H-Indazoles Using N-Fluorobenzenesulfonimide.

An efficient, simple, and metal-free fluorination of 2H-indazoles has been developed using N-fluorobenzenesulfonimide (NFSI) in water under ambient air. This transformation provides direct access to fluorinated indazole derivatives with broad functionalities in satisfactory yields. The experimental results suggest a radical mechanistic pathway of this protocol.

Citation

Payel Ghosh, Alakananda Hajra. Fluorination of 2H-Indazoles Using N-Fluorobenzenesulfonimide. The Journal of organic chemistry. 2021 Aug 06;86(15):10883-10888

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PMID: 34304564

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