Carbol fuchsin stain enhances detection of poly-(d, l-lactide-co-glycolide) microspheres in exenatide extended-release cutaneous injection-site foreign body reaction.

Rebecca Flugrad, Derek Hoerres, Paul B Googe

Journal of cutaneous pathology 2021 Dec

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Injection of high-viscosity fluids into subcutaneous tissues may lead to a granulomatous reaction called sclerosing lipogranuloma (SL). Poly-(d,l-lactide-co-glycolide) (PLG or PLGA) microspheres are used as vehicles for extended-release drugs. Here we describe the histopathologic features of a case of SL induced by exenatide extended-release injections, and the staining pattern of PLG microspheres and microsphere remnants with carbol fuchsin. © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Citation

Rebecca Flugrad, Derek Hoerres, Paul B Googe. Carbol fuchsin stain enhances detection of poly-(d, l-lactide-co-glycolide) microspheres in exenatide extended-release cutaneous injection-site foreign body reaction. Journal of cutaneous pathology. 2021 Dec;48(12):1520-1522