New antimicrobial self-assembling short lipopeptides.

César Vicente-García, Ignacio Colomer

Organic & biomolecular chemistry 2021 Aug 11

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Lipopeptides are an exceptional example of amphiphilic molecules that self-assemble into functional structures with applications in the areas of nanotechnology, catalysis or medicinal chemistry. Herein, we report a library of 21 short lipopeptides, together with their supramolecular characterization and antimicrobial activity against both Gram-negative (E. coli) and Gram-positive (S. aureus) strains. This study shows that simple lipoamino acids self-assemble into micellar or vesicular structures, while incorporating dipeptides capable of stablishing hydrogen bonds results in the adoption of advanced fibrilar structures. The self-assembly effect has proven to be key to achieve antimicrobial activity.

Citation

César Vicente-García, Ignacio Colomer. New antimicrobial self-assembling short lipopeptides. Organic & biomolecular chemistry. 2021 Aug 11;19(31):6797-6803