Complex structures and diverse functions of nuclear bodies: a review].

Xinyuan Liu, Lian-Feng Li, Hua-Ji Qiu

Sheng wu gong cheng xue bao = Chinese journal of biotechnology 2021 Jul 25

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Nuclear bodies are membrane-free nuclear substructures that are localized in the mammalian nuclear matrix region. They are multiprotein complexes that recruit other proteins to participate in various cellular activities, such as transcription, RNA splicing, epigenetic regulation, tumorigenesis and antiviral defense. It is of great significance to clarify the functions and regulatory mechanisms of nuclear bodies to probe related diseases and virus-host interactions. This review takes several nuclear bodies associated proteins as examples, summarizes the formation process, structure and functions of nuclear bodies, and focuses on their important roles in antiviral infection. It is expected to provide new insight into host antiviral mechanisms.

Citation

Xinyuan Liu, Lian-Feng Li, Hua-Ji Qiu. Complex structures and diverse functions of nuclear bodies: a review]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 2021 Jul 25;37(7):2223-2231