Editing linear polyubiquitination of protein substrates by LUBAC and OTULIN is known to play a critical role in immune responses. A recent study by Fu et al. reveals how reversible linear polyubiquitination of the activin receptor-like kinase (ALK1) controls developmental angiogenesis and how its dysfunction leads to vascular malformations in humans. Copyright © 2021 Elsevier Ltd. All rights reserved.
Peter Ten Dijke, David Baker. Fine-tuning ALK1 linear polyubiquitination to control angiogenesis. Trends in cell biology. 2021 Sep;31(9):705-707
PMID: 34330579
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