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Fine-tuning ALK1 linear polyubiquitination to control angiogenesis.

Peter Ten Dijke, David Baker

Trends in cell biology 2021 Sep


filter terms:
  • activin (1)
  • Activin Receptors (2)
  • activin receptors, type ii (2)
  • ALK1 (2)
  • angiogenesis (2)
  • humans (2)
  • signal (1)
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    Editing linear polyubiquitination of protein substrates by LUBAC and OTULIN is known to play a critical role in immune responses. A recent study by Fu et al. reveals how reversible linear polyubiquitination of the activin receptor-like kinase (ALK1) controls developmental angiogenesis and how its dysfunction leads to vascular malformations in humans. Copyright © 2021 Elsevier Ltd. All rights reserved.

    Citation

    Peter Ten Dijke, David Baker. Fine-tuning ALK1 linear polyubiquitination to control angiogenesis. Trends in cell biology. 2021 Sep;31(9):705-707

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    PMID: 34330579

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