Arresting chromosome replication upon energy starvation in Escherichia coli.

Godefroid Charbon, Jakob Frimodt-Møller, Anders Løbner-Olesen

Current genetics 2021 Dec

filter terms:

Most organisms possess several cell cycle checkpoints to preserve genome stability in periods of stress. Upon starvation, the absence of chromosomal duplication in the bacterium Escherichia coli is ensured by holding off commencement of replication. During normal growth, accumulation of the initiator protein DnaA along with cell cycle changes in its activity, ensure that DNA replication starts only once per cell cycle. Upon nutrient starvation, the prevailing model is that an arrest in DnaA protein synthesis is responsible for the absence of initiation. Recent indications now suggest that DnaA degradation may also play a role. Here we comment on the implications of this potential new layer of regulation. © 2021. The Author(s).

Citation

Godefroid Charbon, Jakob Frimodt-Møller, Anders Løbner-Olesen. Arresting chromosome replication upon energy starvation in Escherichia coli. Current genetics. 2021 Dec;67(6):877-882