A selectivity-enhanced ratiometric fluorescence imprinted sensor based on synergistic effect of covalent and non-covalent recognition units for ultrasensitive detection of ribavirin.

Xuelian Hu, Ying Guo, Tao Wang, Chang Liu, Yukun Yang, Guozhen Fang

Journal of hazardous materials 2022 Jan 05

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Development of methods with high selectivity and sensitivity for detection of trace ribavirin (RBV) is of great importance for environmental protection and food safety. Herein, we proposed a simple yet valid strategy to construct the highly selective ratiometric fluorescence sensing platform (BA-LMOFs@MIP) for analysis of RBV based on boric acid-functionalized lanthanide metal-organic framework (BA-LMOFs) coupled with molecularly imprinted polymer (MIP). In this strategy, BA-LMOFs featured with dual-emission and pH-responsive behavior were first synthesized as supporter. Benefiting from boric acid group of BA-LMOFs, RBV was easily immobilized onto its surface, taking advantage of template immobilization-based surface imprinting means to fabricate BA-LMOFs@MIP with dual recognition sites for the first time. The synergistic effect of covalent boronate affinity-based recognition unit and non-covalent imprinting sites enabled BA-LMOFs@MIP to exhibit superior selectivity and binding efficiency to RBV. BA-LMOFs as signal tag endowed BA-LMOFs@MIP with desirable sensitivity, photostability and hydrophilicity. More importantly, BA-LMOFs@MIP-based sensor displayed a wide linear range for RBV from 25 to 1200 ng mL-1 with a detection limit down to 7.62 ng mL-1. The sensor was finally applied to RBV determination in real samples, and the obtained results revealed that BA-LMOFs@MIP would be a promising candidate for monitoring of RBV in complex systems. Copyright © 2021 Elsevier B.V. All rights reserved.

Citation

Xuelian Hu, Ying Guo, Tao Wang, Chang Liu, Yukun Yang, Guozhen Fang. A selectivity-enhanced ratiometric fluorescence imprinted sensor based on synergistic effect of covalent and non-covalent recognition units for ultrasensitive detection of ribavirin. Journal of hazardous materials. 2022 Jan 05;421:126748