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After the emergence of COVID-19 in 2019, it has now become a pandemic. COVID-19 has brought painful disasters to people all over the world. It not only threatens lives and health but also induces economic crises. At present, promising methods to eradicate COVID-19 mainly include drugs and vaccines. Enzyme inhibitors have always been a reliable strategy for the treatment of related diseases. Scientists worldwide have worked together to study COVID-19, obtained the structure of key SARS-CoV-2 associated enzymes, and reported the research of inhibitors of these enzymes. This article summarizes COVID-19-related enzyme inhibitors' recent development, mainly including 3CLpro, PLpro, TMPRSS2, and RdRp inhibitors, hoping to provide valuable weapons in the ensuing battle against COVID-19. Copyright© Bentham Science Publishers; For any queries, please email at


Zhi-Gang Sun, Feng-Ling Yu, Xiang-Ting Qiu, Shuang Li, Xue-Tang Li, Hai-Liang Zhu. Promising Enzymes for Inhibitors Development Against COVID-19. Mini reviews in medicinal chemistry. 2022;22(3):449-456

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PMID: 34353251

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