Neguembor et al. (2021) use super-resolution microscopy to illuminate genome packaging inside the cell nucleus. They discover that transcription and topoisomerases protect chromatin from collapsing in a crumpled state refractory to DNA loop extrusion by cohesin proteins. Copyright © 2021 Elsevier Inc. All rights reserved.
Rini Shah, Elphège P Nora. Transcription and topoisomerases bring new twists to DNA loop extrusion by cohesin. Molecular cell. 2021 Aug 05;81(15):3043-3045
PMID: 34358457
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