Overcoming Chemotherapy Resistance in SCLC.

SCLC is an aggressive form of lung cancer with a very poor prognosis. Although SCLC initially responds very well to platinum-based chemotherapy, it eventually recurs and at recurrence is nearly universally resistant to therapy. In light of the recent advances in understanding regarding the biology of SCLC, we review findings related to SCLC chemotherapy resistance. We discuss the potential clinical implications of recent preclinical discoveries in altered signaling pathways, transcriptional landscapes, metabolic vulnerabilities, and the tumor microenvironment. Copyright © 2021. Published by Elsevier Inc.

Citation

Brett H Herzog, Siddhartha Devarakonda, Ramaswamy Govindan. Overcoming Chemotherapy Resistance in SCLC. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2021 Dec;16(12):2002-2015

Mesh Tags

PMID: 34358725

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