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Six previously undescribed resin glycosides, calyhedins I-VI, were isolated from the rhizomes of Calystegia hederacea Wall., which are the first genuine resin glycosides isolated from C. hederacea. The structures of calyhedins I-VI were determined based on spectroscopic data and chemical evidence. All the compounds have macrolactone structures (jalapins), and their sugar moieties were partially acylated by five organic acids. Calyhedins I, II-V, and VI have 27-, 28-, and 23-membered rings, respectively, and calyhedins IV-VI are the first jalapins with a sugar chain consisting of seven monosaccharides. Additionally, the cytotoxic activity of calyhedins II and III toward HL-60 human promyelocytic leukemia cells was evaluated. Both compounds demonstrated almost the same activity as the positive control, cisplatin. Copyright © 2021 Elsevier Ltd. All rights reserved.


Masateru Ono, Nobuyoshi Yuhara, Takaaki Shimohara, Souta Matsubara, Shin Yasuda, Ryota Tsuchihashi, Masafumi Okawa, Junei Kinjo, Jian-Rong Zhou, Hitoshi Yoshimitsu, Toshihiro Nohara. Calyhedins I-VI: Resin glycosides from the rhizomes of Calystegia hederacea. Phytochemistry. 2021 Oct;190:112888

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PMID: 34358900

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