Therapeutic and preventive effectiveness of zyxorin during poisoning with anticholineesterase pesticides].

N V Kokshareva, Iu S Kagan, L M Ovsiannikova, S Seberini, D Ungvari

Farmakologiia i toksikologiia 1987 Nov-Dec

filter terms:

Zyxorin (50-100 mg/kg) was found to produce a significant increase of the content (activity) of components of electron transport microsomal circuit and is similar to phenobarbital by its inducing effect. At preventive and therapeutic-preventive administration it enhances resistance of albino rats to anticholinesterase pesticides (actellis, valexon, 0,0-dimethyl-0-2,2-dichlorvinylphosphate, clorofos, hostaquick, dioxycarb, primor, sevine, furadan), prevents the development of neuromuscular blockade. The introduction of zyxorin into a complex therapy with specific agents (atropine, reactivators of cholinesterase) potentiates their antidotic effect at poisoning with DDVP.

Citation

N V Kokshareva, Iu S Kagan, L M Ovsiannikova, S Seberini, D Ungvari. Therapeutic and preventive effectiveness of zyxorin during poisoning with anticholineesterase pesticides]. Farmakologiia i toksikologiia. 1987 Nov-Dec;50(6):97-100