Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?

Erin L Sternburg, Lara A Gruijs da Silva, Dorothee Dormann

Trends in biochemical sciences 2022 Jan

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RNA-binding proteins (RBPs) are critical players in RNA expression and metabolism, thus, the proper regulation of this class of proteins is critical for cellular health. Regulation of RBPs often occurs through post-translational modifications (PTMs), which allow the cell to quickly and efficiently respond to cellular and environmental stimuli. PTMs have recently emerged as important regulators of RBPs implicated in neurodegenerative disorders, in particular amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we summarize how disease-associated PTMs influence the biophysical properties, molecular interactions, subcellular localization, and function of ALS/FTD-linked RBPs, such as FUS and TDP-43. We will discuss how PTMs are believed to play pathological, protective, or ambiguous roles in these neurodegenerative disorders. Copyright © 2021 Elsevier Ltd. All rights reserved.

Citation

Erin L Sternburg, Lara A Gruijs da Silva, Dorothee Dormann. Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration? Trends in biochemical sciences. 2022 Jan;47(1):6-22